Call for Industrial Training / Projects in Biopharmaceutical Production Process/
Equipment handling aspect; Engineering aspect; Regulatory aspect
Bangalore Biotech Labs Pvt Ltd., (BiOZEEN), address the areas of challenges of the Biotech Industry though our unique Business Model comprising of Design Build, Consulting and Training, hence serving as a Total Solution Partner and a complete Bioprocess Engineering company for the Biotech World.
BiOZEEN’s training programs address the needs of the biotech industry. Course modules are aligned based on the development in biopharma industrial and regulatory norms
Why training @ BiOZEEN?
- DSIR recognized Bio-pilot training facility
- BCIL recognized company for Biopharma industrial training
- ISO 9001-2008 Certified Training, Evaluation and Certification processes
- Provides practical, intensive hands on training to enrich technical and operational skills
- TRAIN you based on the latest advancements in the Biopharmaceutical Production Industry
- Guidance throughout the training period
- Different programs as per the individual needs
- Experienced faculty from industry, academia.
BiOZEEN Training modules
- Enable understanding of process and equipment design for each of the following:
- Microbial Fermentation
- Animal Cell Culture
- Downstream Processing
- Cleaning, Sterilization & Filtration
- Regulatory Affairs
BiOZEEN Training program Description:
The approach of BiOZEEN training is based on the processes followed in the Biopharmaceutical industry, right from the equipment design, process parameter optimization(inoculum/seeding density, pH etc.,), preparation and filtration of media, scale up of fermentation processes from shake flask to 125L microbial fermentor, handling, maintenance and scale up of animal cell cultures from T-flasks to 5L bioreactor, Downstream processing(TFF, hands on pilot scale Chromatography columns) andprocess/equipment validation of supporting activities like Cleaning In Place, Sterilization In place, autoclave, dry heat sterilizer, integrity testing of filters.
For learning these aspects we have different options, as listed below:
- Basic Training Programs which correspond to summer training, giving you a glimpse of the biopharma production sector
- Advanced training programs to develop your technical skills so as to approach your future employers
- Project works for completing your academic curriculum
Basic Training Program
Basic Training Program on course topic Overview of the Biopharmaceutical production& Bioprocess Engineeringand this training is oriented in upstream and downstream processes of microbial and animal cell culture fermentation. Training fees details will be provided on request.
- Duration of this training is 30 days.
Overview of the Biopharmaceutical production& Bioprocess Engineering
| Introduction to the biopharmaceutical industry |
- Biopharma process & Market Share
- Drug Development Process
- Biopharma facillity requirements & Layout
|
| Basic animal cell culture techniques |
- Cell Banking and Subculturing of BHK 21 cells
- MTT Cytotoxocity assay
- Media preparation & Filtration
|
| Lab scale microbial fermentation |
- Inoculum development
- Operation on 5L fermentor
|
| Downstream Processing Techniques |
- Protein quantification by UV and Bradford methods
- TFF (Ultrafiltration)
- Ion Exchange Chromatography
- SDS PAGE
|
| Sterilization & Filtration technique |
- Familiarization with the industrial Autoclave and DHS
- SIP of process vessel
- Integrity testing
|
| Bioprocess equipment engineering |
- Preparation of valve matrix for process sequences, CIP and SIP for some process equipment
- Preparation of P & ID using ISA based symbols for process equipments
|
Advanced Training Programs
Advanced training programs on course topic Biopharmaceutical Production, Bioprocess Engineering & Regulatory affairsand this training gives complete process knowledge about Biopharma sector. Training fees details will be provided on request.
- Duration of this training is 6 months.
Biopharmaceutical Production, Bioprocess Engineering & Regulatory affairs
| Overview of Biopharmaceutical industry |
- Biopharmaceutical Industry market Share
- Products
- Drug Development Processes
- Steps in Biopharma production
|
| Cell Culture |
- Validation of Bio Safety Cabinet by Settle plate/Plate exposure test
- Growth curve & Serum studies
- Cytotoxicity assay
- Microcarrier culture in 5L Bioreactor
- Cryopreservation
|
| Microbial Fermentation |
- Shake flask optimization studies
- Inoculum development in 5L fermentor
- Fermentation in 40L fermentor
|
| Downstream Processing |
- Filtrations in downstream processing
- Lab scale Chromatography in downstream processing
- Bio-analytical methods and Scale up of chromatography
|
| Cleaning, Sterilization & Filtration |
- Upstream production equipments
- CIP, ESIP & FSIP of Fermentor/Process vessel
- Integrity testing of liquid & air filters
- Sterilization out of place and its challenges
|
| Regulatory Affairs |
- Validation master plan
- Quality risk management
- Facility validation approach
- Qualification of utility Systems & Equipments
- Process validation & Good documentation practices
|
| Bioprocess Equipment Engineering |
- Design of bioreactors &fermentors
- cGMP compliant valves
- Design of CIP systems and process vessels
- Design of filtration system
|
Project Works
Project works will practically educate the students to be proficient in their area of Interest. Fees details will be provided on request.
- Duration of the project work is 3 months
| Cell Culture |
- Optimization of the growth parameters for BHK 21 cells and scale up to 5L bioreactor using different modes of fermentation with microcarrier technology
|
| Microbial Fermentation |
- Optimization of biomass production of E.coli at shake flask and lab scale fermentor
|
| Downstream processing |
- Purification of non recombinant proteins from fermentation broth
|
For any queries contact us at:Bangalore Biotech Labs Pvt. Ltd.
# 49/2, Gubbi Cross, Kothanur Post,
Hennur - Bagalur Road,
Bangalore - 560 077
Karnataka, India
Phone: 080-65309006 /7 / 9
E-mail: trainingenquiry@biozeen.comWebsite: www.biozeen.com
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